Since you seem to be spending the kind of money to improve performance, then I'd also recommend NOt buying the Screamin Eagle Tuner, and going with the Thundermax TTS Mastertune.
More options. True closed loop ECU functions, better O2 sensors and eliminates the factory ECU.
About twice the price, but also twice the performance.
Since the Thundermax works with a base map, then "learns" and changes as needed, the money you's save in remapping and Dyno time to reprogram the SE unit would be put towards the Thundermax unit.
Link to product:
If you get it through Zippers Performance, you'll also note they sell the larger throttle body you're looking for.