Hopefully, you have a bike lift. You can do it with 2 straps from the garage ceiling, but I hate that stuff..........
Jack your bike up.
Once the rear tire is off the ground about 4", take the belt gaurd off.
Undo the cotter pin from the axle nut.
Take the axle nut off.
Sit (yes, sit...) on the ground behind the bike.
Say, "I love cheese." outloud. (Do it....)
Put your right foot (toes) under the tire.
Lift your toes and take the pressure off the tire and unload the weight off the tire/axle.
Slip the axle out. Say "I love cheese" again. (Do it...)
DO NOT move the axle adjusters as although it may seem like a good idea at the time, you create more work later, and I can almost bet, you don't own the $22 belt adjustment tool. (hint, hint) Go buy it, then say, "I love cheese."
As you yank the axle out, the wheel will drop, as will the left and right axle spacers. Keep track of them as one is thicker (left) then the other (right).
Before you drop the wheel, slip the rear brake caliper and holder off the rotor, and out of the swingarm slider. Let it hang GENTLY off the hose, but a bungie cord is better then letting it hang off the hose. Weight on hose=bad.
Drop the wheel to the garage/driveway/kitchen floor. If in the kitchen, post pics. Say "I love cheese."
You'll probably have to hoist the bike up a tad higher to clear the rear fender of a Fatboy. Tilt the tire/wheel (bottom) to the right, and on an angle, slide the whole damn (heavy) thing out. Bottom first, swooping out from under the bike......bottom first....sliding out.......like cheese.........
....yes it's a word...................oh what fun............
Slide said NEW tire on rim back under the fender. (opposite your removal)
Set all your spacers, axle, nut, and right foot back out, in the order they belong and do the dealio like this:
Life the tire/wheel combo onto the top of your right foot/toes back in place. Slide wheel/tire to right.
Put in the left
Get the tire/wheel in place, and hold the axle in your left hand. Yes, it's greasy. No, don't itch your nose, now.
I like to slide the axle though the frame and the left axle adjuster block, and as the wheel lifts up, push the axle through the axle block, spacer and into the left bearing of the wheel.
Take a breath.
Have a smoke/beer/optional activity.
Sit back on the garage, driveway/kitchen floor, and place said foot back under said tire. As you lift it, wrap the belt back around the rear sprocket, and pull it backwards, taking most of the slack back out of it.
Take weight off tire/rim, and push axle through right bearings, and place right spacer on axle. This generally takes 3-4 hands, but you'll figure it out.
Now.......with that being done, there's about 1/8th inch less room that you need to get the brake spacer/mount in the remaining opening, but it'll fit.
Trust me. Then say, "I love cheese" again, outloud.
Tilt the wheel/tire combo to make it level. Slip the brake mount/caliper onto the slider, pushing it forward, and untimately, knocking the right side spacer out, and onto the floor.....at least twice. It's gonna happen.....
Now that you see there's barely enough room, take a thin screw driver, place it gently on the spacer, between the spacer and the brake mount, and slide the brake mount forward to where it belongs. Once you believe it's where it needs to be, slide the axle in the rest of the way, spin the wheel to make sure the caliper/pads and rotor aren't binding, and apply the but, and torque to the correct specs. (about 65 ft/lbs)
Replace belt gaurd.
Eat a ham/cheese sammich.