I have a 09 Tri-Glide that we have put over 35,000 miles on since we got it new. It is our travel bike now. We have done plenty of 2 wheel travel on our previous Harleys. I've been riding over 45 years.
Trikes do ride different than 2 wheelers but it isn't much to get used to.
One downer that has been brought up, you do have 3 points of contact so it is just about imposable to miss the potholes and ruts in the rode.